Effects of the plant-derived hallucinogen salvinorin A on basal dopamine levels in the caudate putamen and in a conditioned place aversion assay in mice: agonist actions at kappa opioid receptors
@article{Zhang2004EffectsOT, title={Effects of the plant-derived hallucinogen salvinorin A on basal dopamine levels in the caudate putamen and in a conditioned place aversion assay in mice: agonist actions at kappa opioid receptors}, author={Yong Zhang and Eduardo R Butelman and Stefan D. Schlussman and Ann Ho and Mary Jeanne Kreek}, journal={Psychopharmacology}, year={2004}, volume={179}, pages={551-558} }
RationaleSalvinorin A is a naturally occurring hallucinogen derived from the plant Salvia divinorum. Salvinorin A is also a potent and selective kappa opioid receptor agonist in vitro. It has been shown that kappa agonists decrease dopamine levels in the caudate putamen and nucleus accumbens and cause conditioned place aversion in rodents.ObjectivesTo study the effects of salvinorin A on basal dopamine levels in the caudate putamen and nucleus accumbens, and to determine whether salvinorin A…
182 Citations
Kappa-opioid receptor-mediated effects of the plant-derived hallucinogen, salvinorin A, on inverted screen performance in the mouse
- Biology, ChemistryBehavioural pharmacology
- 2005
In the mouse, salvinorin A disrupted climbing behavior on an inverted screen task, indicating a rapid, but short-lived induction of sedation/motor incoordination and the possibility that the development of other diterpene-based opioids may yield important therapeutic compounds.
Hallucinatory and rewarding effect of salvinorin A in zebrafish: κ-opioid and CB1-cannabinoid receptor involvement
- Biology, PsychologyPsychopharmacology
- 2006
Results indicate that salvinorin A, as is sometimes reported in humans, exhibits rewarding effects, independently from its motor activity, suggesting the usefulness of the zebrafish model to study addictive behavior.
Depressive-Like Effects of the κ-Opioid Receptor Agonist Salvinorin A on Behavior and Neurochemistry in Rats
- Biology, PsychologyJournal of Pharmacology and Experimental Therapeutics
- 2006
SalvA data provide additional support for the hypothesis that stimulation of brain κ-opioid receptors triggers depressive-like signs in rats and raise the possibility that decreases in extracellular concentrations of DA within the NAc contribute to these effects.
The hallucinogen derived from Salvia divinorum, salvinorin A, has κ-opioid agonist discriminative stimulus effects in rats
- Biology, PsychologyNeuropharmacology
- 2007
Effects of acute and repeated administration of salvinorin A on dopamine function in the rat dorsal striatum
- Biology, MedicinePsychopharmacology
- 2007
Retrodialysis data demonstrate that acute, but not repeated, salvinorin A administration decreases mesostriatal neurotransmission and that activation of DSTR KOPr is sufficient for this effect.
Antinociceptive and Hypothermic Effects of Salvinorin A Are Abolished in a Novel Strain of κ-Opioid Receptor-1 Knockout Mice
- BiologyJournal of Pharmacology and Experimental Therapeutics
- 2006
It is demonstrated that salvinorin A is the active component of S. divinorum, selective for κ1-opioid receptors, and that salvinegorin A and specific structurally related analogs produce behavioral effects that require the κ-opIOid receptor.
Comparison of the discriminative stimulus effects of salvinorin A and its derivatives to U69,593 and U50,488 in rats
- Biology, PsychologyPsychopharmacology
- 2008
These findings support previous reports indicating that the discriminative stimulus effects of salvinorin A are mediated by kappa receptors, and future studies may assist in the development and screening of salvinegorin A analogs for potential pharmacotherapy.
Involvement of κ-Opioid and Endocannabinoid System on Salvinorin A-Induced Reward
- Biology, MedicineBiological Psychiatry
- 2008
Kappa opioid mediation of cannabinoid effects of the potent hallucinogen, salvinorin A, in rodents
- Biology, ChemistryPsychopharmacology
- 2010
These findings suggest that similarities in the pharmacological effects of salvinorin A and those of cannabinoids are mediated by its activation of KOR rather than by any direct action of salvia divinorum A on the endocannabinoid system.
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