Effects of the plant-derived hallucinogen salvinorin A on basal dopamine levels in the caudate putamen and in a conditioned place aversion assay in mice: agonist actions at kappa opioid receptors

@article{Zhang2004EffectsOT,
  title={Effects of the plant-derived hallucinogen salvinorin A on basal dopamine levels in the caudate putamen and in a conditioned place aversion assay in mice: agonist actions at kappa opioid receptors},
  author={Yong Zhang and Eduardo R Butelman and Stefan D. Schlussman and Ann Ho and Mary Jeanne Kreek},
  journal={Psychopharmacology},
  year={2004},
  volume={179},
  pages={551-558}
}
RationaleSalvinorin A is a naturally occurring hallucinogen derived from the plant Salvia divinorum. Salvinorin A is also a potent and selective kappa opioid receptor agonist in vitro. It has been shown that kappa agonists decrease dopamine levels in the caudate putamen and nucleus accumbens and cause conditioned place aversion in rodents.ObjectivesTo study the effects of salvinorin A on basal dopamine levels in the caudate putamen and nucleus accumbens, and to determine whether salvinorin A… 
Kappa-opioid receptor-mediated effects of the plant-derived hallucinogen, salvinorin A, on inverted screen performance in the mouse
TLDR
In the mouse, salvinorin A disrupted climbing behavior on an inverted screen task, indicating a rapid, but short-lived induction of sedation/motor incoordination and the possibility that the development of other diterpene-based opioids may yield important therapeutic compounds.
Hallucinatory and rewarding effect of salvinorin A in zebrafish: κ-opioid and CB1-cannabinoid receptor involvement
TLDR
Results indicate that salvinorin A, as is sometimes reported in humans, exhibits rewarding effects, independently from its motor activity, suggesting the usefulness of the zebrafish model to study addictive behavior.
Depressive-Like Effects of the κ-Opioid Receptor Agonist Salvinorin A on Behavior and Neurochemistry in Rats
TLDR
SalvA data provide additional support for the hypothesis that stimulation of brain κ-opioid receptors triggers depressive-like signs in rats and raise the possibility that decreases in extracellular concentrations of DA within the NAc contribute to these effects.
Effects of acute and repeated administration of salvinorin A on dopamine function in the rat dorsal striatum
TLDR
Retrodialysis data demonstrate that acute, but not repeated, salvinorin A administration decreases mesostriatal neurotransmission and that activation of DSTR KOPr is sufficient for this effect.
The antinociceptive effect of salvinorin A in mice.
Antinociceptive and Hypothermic Effects of Salvinorin A Are Abolished in a Novel Strain of κ-Opioid Receptor-1 Knockout Mice
TLDR
It is demonstrated that salvinorin A is the active component of S. divinorum, selective for κ1-opioid receptors, and that salvinegorin A and specific structurally related analogs produce behavioral effects that require the κ-opIOid receptor.
Comparison of the discriminative stimulus effects of salvinorin A and its derivatives to U69,593 and U50,488 in rats
TLDR
These findings support previous reports indicating that the discriminative stimulus effects of salvinorin A are mediated by kappa receptors, and future studies may assist in the development and screening of salvinegorin A analogs for potential pharmacotherapy.
Kappa opioid mediation of cannabinoid effects of the potent hallucinogen, salvinorin A, in rodents
TLDR
These findings suggest that similarities in the pharmacological effects of salvinorin A and those of cannabinoids are mediated by its activation of KOR rather than by any direct action of salvia divinorum A on the endocannabinoid system.
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