Effects of the partial dopamine receptor agonists SDZ 208-911, SDZ 208-912 and terguride on central monoamine receptors

@article{Svensson1991EffectsOT,
  title={Effects of the partial dopamine receptor agonists SDZ 208-911, SDZ 208-912 and terguride on central monoamine receptors},
  author={K. -G. Svensson and Agneta Ekman and Montford F. Piercey and William E. Hoffmann and Janet T. Lum and Arvid Carlsson},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={1991},
  volume={344},
  pages={263-274}
}
The partial dopamine receptor agonists SDZ 208-911 {N-[(8-alpha)-2,6-dimethylergoline-8-yl]-2,2-dimethylpropanamide|, and terguride (transdihydrolisuride; TDHL) were tested in biochemical, behavioral (locomotor activity) and electrophysiological assays in male rats. In reserpine-pretreated rats, SDZ 208-911 and terguride dose-dependently reduced striatal DOPA formation (NSD 1015 treatment) with similar efficacy (−80%) and potency as the selective D2 receptor agonist quinpirole (LY 171555). SDZ… CONTINUE READING
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