Effects of the novel dual inhibitor of neutral endopeptidase and angiotensin-converting enzyme, CGS 30440, on blood pressure and cardiac hypertrophy in spontaneously hypertensive rats.

@article{Webb1997EffectsOT,
  title={Effects of the novel dual inhibitor of neutral endopeptidase and angiotensin-converting enzyme, CGS 30440, on blood pressure and cardiac hypertrophy in spontaneously hypertensive rats.},
  author={R. Webb and M. Abramson and M. Beil and L. Odorico and R. Chatelain},
  journal={Journal of cardiovascular pharmacology},
  year={1997},
  volume={30 5},
  pages={
          632-42
        }
}
This study examined the long-term effects of CGS 30440 on blood pressure, heart rate, cardiac hypertrophy, and urinary parameters in conscious spontaneously hypertensive rats (SHRs) and Wistar-Kyoto (WKY) rats. Initial studies with CGS 30440 produced dose-related reductions in mean arterial pressure, with a dose of 30 mg/kg/day of CGS 30440 producing a maximal sustained response of 40 mm Hg. CGS 30440 significantly inhibited plasma angiotensin-converting enzyme (ACE) activity by 82% in WKY rats… Expand
Antihypertensive and natriuretic effects of CGS 30440, a dual inhibitor of angiotensin-converting enzyme and neutral endopeptidase 24.11.
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Omapatrilat Induces Profound Renal Vasodilation but Does Not Affect Coronary Hemodynamics
Bradykinin metabolism in the postinfarcted rat heart: role of ACE and neutral endopeptidase 24.11.
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