• DOI:10.1097/00005344-199711000-00014
Corpus ID: 12036185

Effects of the novel dual inhibitor of neutral endopeptidase and angiotensin-converting enzyme, CGS 30440, on blood pressure and cardiac hypertrophy in spontaneously hypertensive rats.

@article{Webb1997EffectsOT,
  title={Effects of the novel dual inhibitor of neutral endopeptidase and angiotensin-converting enzyme, CGS 30440, on blood pressure and cardiac hypertrophy in spontaneously hypertensive rats.},
  author={R. Webb and M. Abramson and M. Beil and L. Odorico and R. Chatelain},
  journal={Journal of cardiovascular pharmacology},
  year={1997},
  volume={30 5},
  pages={
          632-42
        }
}

• R. Webb, M. Abramson, +2 authors R. Chatelain
• Published 1997
• Medicine
• Journal of cardiovascular pharmacology

This study examined the long-term effects of CGS 30440 on blood pressure, heart rate, cardiac hypertrophy, and urinary parameters in conscious spontaneously hypertensive rats (SHRs) and Wistar-Kyoto (WKY) rats. Initial studies with CGS 30440 produced dose-related reductions in mean arterial pressure, with a dose of 30 mg/kg/day of CGS 30440 producing a maximal sustained response of 40 mm Hg. CGS 30440 significantly inhibited plasma angiotensin-converting enzyme (ACE) activity by 82% in WKY rats… Expand

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