Effects of the novel anti‐inflammatory drugs robenacoxib and AHI‐805 on recovery of ischemic injured equine jejunum ex vivo

@article{Marshall2009EffectsOT,
  title={Effects of the novel anti‐inflammatory drugs robenacoxib and AHI‐805 on recovery of ischemic injured equine jejunum ex vivo},
  author={John F Marshall and Adria S. Bhatnagar and Susan G. Bowman and Natalie N. Morris and Dinah A. Skorich and Anthony T. Blikslager},
  journal={The FASEB Journal},
  year={2009},
  volume={23}
}
Flunixin is an NSAID administered to horses to ameliorate shock, but which inhibits recovery of barrier function in ischemic‐injured intestine. We examined the effect of robenacoxib, a COX‐2 inhibitor, and AHI‐805, an aza‐thia‐benzoazulene derivative, on recovery of mucosal barrier function. Jejunum was subjected to ischemia for 2 hours in 6 horses. Control and ischemic‐injured mucosa was treated with Ringer's alone (control) or containing 0.27μM flunixin, robenacoxib, or AHI‐805 in Ussing…