Effects of the non-selective beta-adrenoceptor blocking agent, carteolol, on platelet function, blood coagulation and viscosity.

@article{Small1982EffectsOT,
  title={Effects of the non-selective beta-adrenoceptor blocking agent, carteolol, on platelet function, blood coagulation and viscosity.},
  author={Michael Small and J. T. Douglas and G. Wynne Aherne and M. Orr and Gordon D. O. Lowe and Charles D. Forbes and Colin R. M. Prentice},
  journal={Thrombosis research},
  year={1982},
  volume={25 4},
  pages={
          351-60
        }
}
View on PubMed
doi.org
11 Citations
Background Citations
1

11 Citations

Lack of significant effect of therapeutic propranolol on measurable platelet function in healthy subjects.

It is suggested that propranolol does not significantly affect platelet function when taken at doses commonly encountered in clinical practice, despite minor changes reaching significance with some agonists.

Lack of significant effect of therapeutic propranolol on measurable platelet function in healthy subjects.

It is suggested that propranolol does not significantly affect platelet function when taken at doses commonly encountered in clinical practice, despite minor changes reaching significance with some agonists.

Beta-adrenoceptor antagonists and human platelets: relationship of effects to lipid solubility.

Inhibition of thromboxane and prostacyclin production in whole blood by adrenoceptor antagonists.

Increased platelet adhesion and aggregation in hypertensive patients: effect of atenolol.

Fourteen patients with established hypertension followed a double-blind crossover-styled trial to study the effects of 100 mg/day atenolol compared to placebo. Atenolol was found to be an effective…

Effects of Stress and 3-Blockade on Platelet Function

There is a need for well-conducted studies assessing platelet function in vivo during fl-blockade to evaluate whether platelet responses contribute to favorable effects of fl- blockade in unstable angina, for example, or after myocardial infarction.

Vasodilating β-adrenoceptor blockers as cardiovascular therapeutics

Potential Protective Role of Blood Pressure-Lowering Drugs on the Balance between Hemostasis and Fibrinolysis in Hypertensive Patients at Rest and During Exercise

  • A. Braschi
  • Medicine
    American Journal of Cardiovascular Drugs
  • 2019
The scientific evidence regarding some biological effects of antihypertensive drugs, which can protect patients from the adverse consequences of hypertensive disease, improving endothelial function, enhancing antioxidant activity, and restoring equilibrium between hemostatic and fibrinolytic factors are reviewed.

Effect of β‐blockers on platelet aggregation: a systematic review and meta‐analysis

The aim of this study was to perform a systematic review and meta‐analysis of the effect of β‐blockers on platelet aggregation.

Plasma levels of platelet secretory proteins.

References

SHOWING 1-10 OF 26 REFERENCES

β-Blocking Agents and Platelet Aggregation

Propranolol proved also to be a powerful inhibitor of adenosine diphosphate (ADP)-induced aggregation and of potentiating effect of epinephrine on the second phase of ADP-induced aggregation, which seems to have a stabilizing action on biological membranes like imipramine and related compounds.

Effect of propranolol on platelet function.

It is suggested that propranolol, like local anesthetics, decreased platelet responsiveness by a direct action on the platelet membrane, possibly by interfering with calcium availability.

Alterations of fibrinolysis and blood coagulation induced by exercise, and the role of beta-adrenergic-receptor stimulation.

The influence of combined treatment with propranolol and acetylsalicylic acid on platelet aggregation in coronary heart disease.

The study showed that propranolol besides its well-known hemodynamic effects had an additional antiaggregating property, and the action of combined treatment with proPRanolol and ASA on platelet aggregation is probably additive.

The effect of a single dose of propranolol on human erythrocytes in vivo

In vitro propranolol has a profound effect on erythrocytes as indicated by a decrease of the packed cell volume and a shift to the right of the oxygen dissociation curve, which is of interest in view of the use of betablocking agents in critically ill patients.

Effects of propranolol and metoprolol on the peripheral circulation.

Both drugs reduced post-exercise muscle hyperaemia, propranolol by more than metoprolol, and should be used with care in patients with known vascular disease.

Platelet function in hyperlipoproteinemia.

The data suggest that heightened platelet function is associated with the thrombotic complications and accelerated atherogenesis of Type II hyperlipoproteinemia.

Some observations on propranolol on platelet aggregation and release

Platelet function was investigated in four normal volunteers, one patient with a mild form of von Willebrand disease, and one with a thrombocytopathy, all taking propranolol. No effect on platelet…

Abrupt propranolol withdrawal in angina pectoris: effects on platelet aggregation and exercise tolerance.

CHARACTERIZATION OF RECEPTORS MEDIATING 5‐HYDROXYTRYPTAMINE‐ AND CATECHOLAMINE‐INDUCED PLATELET AGGREGATION, ASSESSED BY THE ACTIONS OF α‐ AND β‐BLOCKERS, BUTYROPHENONES, 5‐HT ANTAGONISTS AND CHLORPROMAZINE

The effects of 5‐HT antagonists, α‐ and β‐adrenoceptor blocking agents, butyrophenones and chlorpromazine upon aggregation induced by the four amines were investigated and only phentolamine was a potent inhibitor of the catecholamine‐induced aggregation.