Effects of the new arginase inhibitor N(omega)-hydroxy-nor-L-arginine on NO synthase activity in murine macrophages.

@article{Tenu1999EffectsOT,
  title={Effects of the new arginase inhibitor N(omega)-hydroxy-nor-L-arginine on NO synthase activity in murine macrophages.},
  author={J. P. Tenu and Michel Lepoivre and Catherine Moali and Maurice Brollo and Daniel Mansuy and Jean Luc Boucher},
  journal={Nitric oxide : biology and chemistry},
  year={1999},
  volume={3 6},
  pages={
          427-38
        }
}
In stimulated murine macrophage, arginase and nitric oxide synthase (NOS) compete for their common substrate, l-arginine. The objectives of this study were (i) to test the new alpha-amino acid N(omega)-hydroxy-nor-l-arginine (nor-NOHA) as a new selective arginase inhibitor and (ii) to elucidate the effects of arginase inhibition on l-arginine utilization by an inducible NOS. Nor-NOHA is about 40-fold more potent than N(omega)-hydroxy-l-arginine (NOHA), an intermediate in the l-arginine/NO… CONTINUE READING
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