Effects of the mutations Ala30 to Pro and Ala53 to Thr on the physical and morphological properties of alpha-synuclein protein implicated in Parkinson's disease.

@article{ElAgnaf1998EffectsOT,
  title={Effects of the mutations Ala30 to Pro and Ala53 to Thr on the physical and morphological properties of alpha-synuclein protein implicated in Parkinson's disease.},
  author={Omar M. A. El-Agnaf and Ross Jakes and Martin David Curran and Andrew Wallace},
  journal={FEBS letters},
  year={1998},
  volume={440 1-2},
  pages={67-70}
}
Alpha-synuclein (alpha-syn) protein has been found in association with the pathological lesions of a number of neurodegenerative diseases. Recently, mutations in the alpha-syn gene have been reported in families susceptible to an inherited form of Parkinson's disease. We report here that human wild-type alpha-syn, PD-linked mutant alpha-syn(Ala30Pro) and… CONTINUE READING