Effects of the mono- and tetrasialogangliosides GM1 and GQ1b on ATP-induced long-term potentiation in hippocampal CA1 neurons.

@article{Fujii2002EffectsOT,
  title={Effects of the mono- and tetrasialogangliosides GM1 and GQ1b on ATP-induced long-term potentiation in hippocampal CA1 neurons.},
  author={Satoshi Fujii and Kotaro Igarashi and Hiroshi Sasaki and Hidekazu Furuse and Ken-ichi Ito and Kenya Kaneko and Hiroshi Kato and Jin-ichi Inokuchi and Hatsue Waki and Susumu Ando},
  journal={Glycobiology},
  year={2002},
  volume={12 5},
  pages={339-44}
}
The effects of the mono- and tetrasialogangliosides, GM1 and GQ1b, on ATP-induced long-term potentiation (LTP) were studied in CA1 neurons of guinea pig hippocampal slices. Application of 5 or 10 microM ATP for 10 min resulted in a transient depression followed by a slow augmentation of synaptic transmission, leading to LTP. LTP induced by treatment with 5 microM ATP was facilitated in hippocampal slices prepared from animals treated for 6 days with a ceramide analog, L-threo-1-phenyl-2… CONTINUE READING

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