Effects of the maleless mutation on X and autosomal gene expression in Drosophila melanogaster.

@article{Hiebert1994EffectsOT,
  title={Effects of the maleless mutation on X and autosomal gene expression in Drosophila melanogaster.},
  author={J C Hiebert and James A. Birchler},
  journal={Genetics},
  year={1994},
  volume={136 3},
  pages={913-26}
}
The mutational effect of the maleless (mle) gene in Drosophila has been reexamined. Earlier work had suggested that mle along with other male-lethal genes was responsible for hypertranscription of the X chromosome in males to bring about dosage compensation. Prompted by studies on dosage sensitive regulatory genes, we tested for effects of mlets on the phenotypes of 16 X or autosomal mutations in adult escapers of lethality. In third instar larvae, prior to the major lethal phase of mle, we… CONTINUE READING
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