Effects of the leukotrienes on the vasculature and blood pressure of different species.

@article{Berkowitz1984EffectsOT,
  title={Effects of the leukotrienes on the vasculature and blood pressure of different species.},
  author={Bruce A. Berkowitz and B Zabko-Potapovich and Richard E Valocik and John G Gleason},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={1984},
  volume={229 1},
  pages={105-12}
}
We have examined in these studies the contractile activity of leukotrienes (LTs) C4, D4 and E4 on vascular ring segments obtained from several species and demonstrated that the distal segment of the guinea-pig pulmonary artery is a useful and convenient preparation for the study of LT vascular pharmacology. In vitro, LTs had no effect on aortic rings from rats, rabbits or guinea pigs. In contrast, LTs produced significant contraction of the distal portion of the pulmonary artery of the guinea… CONTINUE READING

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