Effects of the ionophore X‐537A on acetylcholine release at the frog neuromuscular junction.

@article{Kita1976EffectsOT,
  title={Effects of the ionophore X‐537A on acetylcholine release at the frog neuromuscular junction.},
  author={H. Kita and W. G. Van der Kloot},
  journal={The Journal of Physiology},
  year={1976},
  volume={259}
}
  • H. Kita, W. G. Van der Kloot
  • Published 1976
  • Chemistry, Medicine
  • The Journal of Physiology
  • 1. X‐537A is an ionophore that can carry cations across cell membranes. We studied its effects on spontaneous and stimulated quantal acetylcholine (ACh) release at the frog neuromuscular junction. 2. When neuromuscular transmission was blocked with high Mg2+ or with curare, X‐537A markedly increased the end‐plate potential (e.p.p.) amplitude. Then a few minutes later the e.p.p. disappeared. 3. When neuromuscular transmission was blocked with hypertonic saline solution, X‐537A did not increase e… CONTINUE READING
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