Effects of the in vivo supply of butyrate on histone acetylation of cecum in piglets.

@article{Kien2008EffectsOT,
  title={Effects of the in vivo supply of butyrate on histone acetylation of cecum in piglets.},
  author={Craig Lawrence Kien and Cheryl P Peltier and Soma Mandal and James R. Davie and Ruth Blauwiekel},
  journal={JPEN. Journal of parenteral and enteral nutrition},
  year={2008},
  volume={32 1},
  pages={51-6}
}
BACKGROUND In vitro, butyrate inhibits histone deacetylase and down-regulates expression of cyclin D1. We hypothesized that an increased entry rate of butyrate into the cecal lumen would have similar effects in vivo. METHODS We used frozen cecal tissue and data from previous studies, one showing that lactulose supplementation caused an increased rate of cecal synthesis of butyrate and decreased cecal cell proliferation and density of clostridia and the other showing that cecal cell… CONTINUE READING