Effects of the histone deacetylases inhibitors sodium butyrate and trichostatin A on the inhibition of gap junctional intercellular communication by H2O2- and 12-O-tetradecanoylphorbol-13-acetate in rat liver epithelial cells.

Abstract

The histone deacetylase (HDAC) inhibitors, trichostatin A (TSA) and sodium butyrate (NaBu) are considered as potent therapeutic agents for cancer treatment presenting therapeutic benefits with less risk of side effects. The microbial metabolite, TSA is a potent reversible and highly specific inhibitor of mammalian histone deacetylases. NaBu causes… (More)

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@article{Jung2006EffectsOT, title={Effects of the histone deacetylases inhibitors sodium butyrate and trichostatin A on the inhibition of gap junctional intercellular communication by H2O2- and 12-O-tetradecanoylphorbol-13-acetate in rat liver epithelial cells.}, author={Ji-Won Jung and Sung-Dae Cho and Nam-shik Ahn and S R Eric Yang and Joon-Suk Park and Eun-hye Jo and Jae-Woong Hwang and Okezie I. Aruoma and Yong-Soon Lee and Kyung-Sun Kang}, journal={Cancer letters}, year={2006}, volume={241 2}, pages={301-8} }