Effects of the endothelin receptor antagonist bosentan on hemodynamics, symptoms and functional capacity in Japanese patients with severe pulmonary hypertension.

@article{Sasayama2005EffectsOT,
  title={Effects of the endothelin receptor antagonist bosentan on hemodynamics, symptoms and functional capacity in Japanese patients with severe pulmonary hypertension.},
  author={Shigetake Sasayama and Takeyoshi Kunieda and Hitonobu Tomoike and Masunori Matsuzaki and Kunio Shirato and Takayuki Kuriyama and Tohru Izumi and Hideki Origasa and Paul L. M. van Giersbergen and Jasper Dingemanse and Satoshi Tanaka},
  journal={Circulation journal : official journal of the Japanese Circulation Society},
  year={2005},
  volume={69 2},
  pages={131-7}
}
BACKGROUND Endothelin (ET)-1 has a pathogenic role in pulmonary arterial hypertension (PAH). Recent clinical studies carried out in Western populations showed that blockade of the ET receptors by bosentan improves pulmonary hemodynamics and exercise capacity. In the present study, the efficacy of bosentan was assessed in Japanese patients with PAH. METHOD AND RESULTS Because the pharmacokinetics of bosentan and its metabolites are similar in Japanese and Caucasian subjects, the same dose of… CONTINUE READING

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