Effects of the competitive nicotinic antagonist erysodine on behavior occasioned or maintained by nicotine: comparison with mecamylamine

@article{Mansbach2000EffectsOT,
  title={Effects of the competitive nicotinic antagonist erysodine on behavior occasioned or maintained by nicotine: comparison with mecamylamine},
  author={Robert S. Mansbach and Leslie K. Chambers and Charles C. Rovetti},
  journal={Psychopharmacology},
  year={2000},
  volume={148},
  pages={234-242}
}
Rationale: The cellular effects of nicotine underlying its addictive liability are thought to be mediated by neuronal nicotinic receptors (nACHRs) in the central nervous system. It is believed that densely expressed β2-containing nACHRs in the central nervous system are responsible for these actions, but few data are available that can directly assess subtype mediation of nicotine’s acute subjective and reinforcing effects. Objective: The present study compared the effects of the competitive… CONTINUE READING
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