Effects of the combination of vitamin K and teriparatide on the bone metabolism in ovariectomized rats.

@article{Nagura2015EffectsOT,
  title={Effects of the combination of vitamin K and teriparatide on the bone metabolism in ovariectomized rats.},
  author={Nana Nagura and Jun Komatsu and Hideaki Iwase and Hiroshi Hosoda and Osamu Ohbayashi and Isao Nagaoka and Kazuo Kaneko},
  journal={Biomedical reports},
  year={2015},
  volume={3 3},
  pages={295-300}
}
The purpose of the present study was to evaluate the combined effects of vitamin K (VK) and teriparatide (TPTD) on bone mineral density (BMD), mechanical strength and other parameters for bone metabolism using a rat ovariectomized osteoporosis model. Ovariectomized female Sprague-Dawley rats were administered with VK (an oral dose of 30 mg/kg/day), TPTD (a subcutaneous dose of 30 µg/kg, three times a week) or a combination for 8 weeks. Thereafter, serum levels of γ-carboxylated osteocalcin (Gla… CONTINUE READING