Effects of the circadian rhythm gene period 1 (per1) on psychosocial stress-induced alcohol drinking.

  title={Effects of the circadian rhythm gene period 1 (per1) on psychosocial stress-induced alcohol drinking.},
  author={Li Dong and Ainhoa Bilbao and Manfred Laucht and Richard Henriksson and Tatjana Yakovleva and Monika Ridinger and Sylvane Desrivi{\`e}res and Toni-Kim Clarke and Anbarasu Lourdusamy and Michael N. Smolka and Sven Cichon and Dorothea Blomeyer and Jens Treutlein and St{\'e}phanie Perreau-Lenz and Stephanie H. Witt and Fernando Leonardi-Essmann and Norbert Wodarz and Peter Zill and Michael Soyka and Urs Albrecht and Marcella Rietschel and Mark Lathrop and Georgy Bakalkin and Rainer Spanagel and Gunter Schumann},
  journal={The American journal of psychiatry},
  volume={168 10},
OBJECTIVE Circadian and stress-response systems mediate environmental changes that affect alcohol drinking. Psychosocial stress is an environmental risk factor for alcohol abuse. Circadian rhythm gene period 1 (Per1) is targeted by stress hormones and is transcriptionally activated in corticotropin releasing factor-expressing cells. The authors hypothesized that Per1 is involved in integrating stress response and circadian rhythmicity and explored its relevance to alcohol drinking. METHOD In… CONTINUE READING
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