Effects of the chemokine CCL2 on blood-brain barrier permeability during ischemia-reperfusion injury.

@article{Dimitrijevic2006EffectsOT,
  title={Effects of the chemokine CCL2 on blood-brain barrier permeability during ischemia-reperfusion injury.},
  author={Oliver B Dimitrijevic and Svetlana M. Stamatovic and Richard F. Keep and Anuska V. Andjelkovic},
  journal={Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism},
  year={2006},
  volume={26 6},
  pages={
          797-810
        }
}
The chemokine CCL2 is considered as one of the main effectors driving postischemic infiltration of monocytes into the brain parenchyma. New experimental data, however, suggest that CCL2 could also participate in blood-brain barrier (BBB) 'opening' during the transmigration of monocytes. The current study examines the role of CCL2 in regulating BBB permeability after ischemia in vitro. To address this issue, an in vitro BBB model (coculture of astrocytes and brain endothelial cells) was… CONTINUE READING
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