Effects of the centrally acting cholinesterase inhibitors tetrahydroaminoacridine and E2020 on the basal concentration of extracellular acetylcholine in the hippocampus of freely moving rats

@article{Kawashima1994EffectsOT,
  title={Effects of the centrally acting cholinesterase inhibitors tetrahydroaminoacridine and E2020 on the basal concentration of extracellular acetylcholine in the hippocampus of freely moving rats},
  author={Koichiro Kawashima and Akio Sato and Masayuki Yoshizawa and Takeshi Fujii and Kazuko Fujimoto and Takeshi Suzuki},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
  year={1994},
  volume={350},
  pages={523-528}
}
The effects of the centrally acting cholinesterase (ChE) inhibitors, tetrahydroaminoacridine (THA) and E2020 (1-benzyl-4-[(5,6-dimethoxy-l-indanon)-2-yl] methylpiperidine hydrochloride), potential drugs for the treatment of senile dementia, on the basal extracellular acetylcholine (ACh) concentration in the hippocampus of freely moving rats, were determined using a microdialysis technique without the use of a ChE inhibitor in the perfusion fluid and a sensitive RIA. The mean (±SEM) basal ACh… CONTINUE READING