Effects of the capsaicin analogue resiniferatoxin on spinal nociceptive mechanisms in the rat: behavioral, electrophysiological and in situ hybridization studies.

@article{Xu1997EffectsOT,
  title={Effects of the capsaicin analogue resiniferatoxin on spinal nociceptive mechanisms in the rat: behavioral, electrophysiological and in situ hybridization studies.},
  author={X Jing Xu and T. Farkas-Szallasi and Jan M. Lundberg and Tomas G M H{\"o}kfelt and Zsuzsanna Wiesenfeld-Hallin and Arpad Szallasi},
  journal={Brain research},
  year={1997},
  volume={752 1-2},
  pages={52-60}
}
The effect of a single subcutaneous (s.c.) injection of the ultrapotent capsaicin analogue resiniferatoxin (RTX) on responses of adult rats to noxious thermal and mechanical stimulation was examined. The effects of RTX treatment on the nociceptive flexor reflex and activity-dependent increase in spinal excitability after conditioning C-fiber stimulation (CS) were also assessed. Finally, the expression of galanin message associated peptide (GMAP) mRNA in dorsal root ganglion (DRG) cells and the… CONTINUE READING