Effects of the bone morphogenetic protein binding protein spp24 (secreted phosphoprotein 24 kD) on the growth of human lung cancer cells.

Abstract

Bone morphogenetic proteins (BMPs) and transforming growth factor-beta (TGF-β) contribute to the growth of some skeletal metastases through autocrine stimulation. Secreted phosphoprotein 24 kDa (spp24) has been shown to bind to both BMP-2 and TGF-β and to markedly inhibit the osteogenic properties of rhBMP-2. We hypothesized that the addition of spp24 would… (More)
DOI: 10.1002/jor.21383

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@article{Lee2011EffectsOT, title={Effects of the bone morphogenetic protein binding protein spp24 (secreted phosphoprotein 24 kD) on the growth of human lung cancer cells.}, author={K R Lee and Samuel Murray and Maria Eug{\^e}nia Leite Duarte and Juliana F Spitz and Jared S. Johnson and Kyung-Jin Song and Elsa J. Brochmann and Cyrus E. Taghavi and Gun Keorochana and Jen-Chung Liao and Jeffrey C Wang}, journal={Journal of orthopaedic research : official publication of the Orthopaedic Research Society}, year={2011}, volume={29 11}, pages={1712-8} }