Effects of the bone morphogenetic protein binding protein spp24 (secreted phosphoprotein 24 kD) on the growth of human lung cancer cells.

@article{Lee2011EffectsOT,
  title={Effects of the bone morphogenetic protein binding protein spp24 (secreted phosphoprotein 24 kD) on the growth of human lung cancer cells.},
  author={K B M Lee and Samuel S. Murray and Maria Eugenia Leite Duarte and Juliana F Spitz and J. S. Johnson and K Y Song and Elsa J. Brochmann and Cyrus E. Taghavi and Gun Keorochana and J J Liao and Jeffrey C Wang},
  journal={Journal of orthopaedic research : official publication of the Orthopaedic Research Society},
  year={2011},
  volume={29 11},
  pages={1712-8}
}
Bone morphogenetic proteins (BMPs) and transforming growth factor-beta (TGF-β) contribute to the growth of some skeletal metastases through autocrine stimulation. Secreted phosphoprotein 24 kDa (spp24) has been shown to bind to both BMP-2 and TGF-β and to markedly inhibit the osteogenic properties of rhBMP-2. We hypothesized that the addition of spp24 would sequester autocrine growth factors (especially BMP-2) and reduce tumor growth in a system (A549 human non-small cell lung cancer cell line… CONTINUE READING
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