Effects of the beta3-adrenergic agonist BRL 37344 on endothelial nitric oxide synthase phosphorylation and force of contraction in human failing myocardium.

@article{Napp2009EffectsOT,
  title={Effects of the beta3-adrenergic agonist BRL 37344 on endothelial nitric oxide synthase phosphorylation and force of contraction in human failing myocardium.},
  author={Andreas Napp and Klara Brixius and Christian Pott and Christoph Ziskoven and Birgit Boelck and Uwe Mehlhorn and Robert H. G. Schwinger and Wilhelm Bloch},
  journal={Journal of cardiac failure},
  year={2009},
  volume={15 1},
  pages={57-67}
}
BACKGROUND In nonfailing myocardium, beta(3)-adrenergic signaling causes a decrease in contractility via endothelial nitric oxide synthase (eNOS) activation and nitric oxide (NO) release. This study investigates the hypothesis that beta(3)-adrenergic signaling undergoes alterations in failing myocardium. METHODS We compared eNOS- and beta(3)-adrenoceptor expression using Western blot analysis in human nonfailing myocardium versus failing myocardium. With the use of immunohistochemistry, we… CONTINUE READING