Effects of the atrial antiarrhythmic drug AVE0118 on cardiac ion channels

  title={Effects of the atrial antiarrhythmic drug AVE0118 on cardiac ion channels},
  author={Heinz Goegelein and Joachim Brendel and Klaus Steinmeyer and Carsten Str{\"u}bing and Nicolas Picard and David E Rampe and Karin Kopp and A. E. Busch and Markus Bleich},
  journal={Naunyn-Schmiedeberg's Archives of Pharmacology},
Previous studies in pigs and goats have demonstrated that AVE0118 prolongs atrial refractoriness without any effect on the QT-interval. The purpose of the present study was to investigate the effect of the compound on various cardiac ion channels. AVE0118 blocked the pig Kv1.5 and the human Kv1.5 expressed in Xenopus oocytes with IC50 values of 5.4±0.7 μM and 6.2±0.4 μM respectively. In Chinese hamster ovary (CHO) cells, AVE0118 decreased the steady-state hKv1.5 current with an IC50 of 1.1±0.2… CONTINUE READING


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Effects of AVE0118, a novel inhibitor of atrial K channels, on action potentials in isolated atria

  • H Gögelein, J Brendel, AE Busch, M Bleich
  • Naunyn-Schmiedebergs Arch Pharmacol
  • 2004
1 Excerpt

AVE0118, an antiarrhythmic drug with novel mechanism of action-Block of IKur and Ito potassium currents in human atrial myocytes

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  • Circulation
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