Effects of the aqueous extract from Salvia miltiorrhiza Bunge on caffeine pharmacokinetics and liver microsomal CYP1A2 activity in humans and rats.

Abstract

OBJECTIVES The effects of the aqueous extract of Salvia miltiorrhiza Bunge (Danshen) on metabolism/pharmacokinetics of caffeine and on liver microsomal CYP1A2 activity in humans and rats have been investigated. METHODS The effects of Danshen aqueous extract on CYP1A2 activity were determined by metabolism of model substrates in the rat in vivo and in… (More)
DOI: 10.1111/j.2042-7158.2010.01127.x

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@article{Wang2010EffectsOT, title={Effects of the aqueous extract from Salvia miltiorrhiza Bunge on caffeine pharmacokinetics and liver microsomal CYP1A2 activity in humans and rats.}, author={Xin Wang and John Hok Keung Yeung}, journal={The Journal of pharmacy and pharmacology}, year={2010}, volume={62 8}, pages={1077-83} }