Effects of the antiestrogens tamoxifen and clomiphene on bone resorption in vitro.

@article{Stewart1986EffectsOT,
  title={Effects of the antiestrogens tamoxifen and clomiphene on bone resorption in vitro.},
  author={P. J. Stewart and P. Stern},
  journal={Endocrinology},
  year={1986},
  volume={118 1},
  pages={
          125-31
        }
}
The in vitro effect of the nonsteroidal antiestrogens tamoxifen (TAM) and clomiphene (CLO) on bone resorption was investigated. TAM (100 microM) and CLO (100 microM) completely blocked PTH (2 nM)-induced resorption; 10 microM TAM was ineffective in blocking resorption, while 40-50 microM partially inhibited the response. TAM (100 microM) also completely blocked prostaglandin E2 (30 nM)- and 1,25-dihydroxy vitamin D3 (0.5 nM)-induced bone resorption. A 16-h pretreatment with TAM blocked… Expand
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  • Chemistry, Medicine
  • Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
  • 1986
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