Effects of the anti-inflammatory serine esterase inhibitor, FOY, on phospholipase A2 (EC activity in rabbit polymorphonuclear leukocytes.


Phospholipase A2 activity of polymorphonuclear leukocytes (PMNLs) towards radioactively labelled phosphatidylethanolamine is inhibited by FOY (ethyl 4-(6-guanidinohexanoyloxy)-benzoate methanesulfonate) in concentrations above 10(-4)M. The inhibition is noncompetitive with respect to the substrate employed and depends on the pH. Impairment of PMNL… (More)


  • Presentations referencing similar topics