Effects of the acute administration of caffeine in patients with schizophrenia.

  title={Effects of the acute administration of caffeine in patients with schizophrenia.},
  author={P B Lucas and David Pickar and John Kelsoe and Mark Hyman Rapaport and Carlos N. Pato and Daniel Hommer},
  journal={Biological psychiatry},
  volume={28 1},
Caffeine, 10 mg/kg, was administered to 13 schizophrenic patients in a double-blind placebo-controlled study of its behavioral effects. Some measures of psychopathology were significantly increased: Brief Psychiatric Rating Scale (BPRS) total, BPRS subscales thought disorder, unusual thought content, and euphoria-activation, and several individual BPRS items. Nurses' Bunney-Hamberg ratings of psychosis and mania, comparing the day before with the day after pharmacological challenge, increased… CONTINUE READING


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