Effects of the Tumor Promoter 12-O-Tetradecanoylphorbol-13-acetate on Neurite Outgrowth from Chick Embryo Sensory Ganglia1


The addition of the phorbol ester 12-O-tetradecanoylphorbol13-acetate (TPA) to defined growth medium stimulated an in tense neurite outgrowth from chick sensory ganglia expiants. The development of radial neuntes was concentration depend ent. At low concentrations of TPA (1.6 to 16 nw), neuntes were long but moderate in numbers. At higher concentrations… (More)


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