Effects of the PPARgamma agonist GW1929 on muscle wasting in tumour-bearing mice.


Administration of the PPARgamma agonist GW1929 (10 mg/kg body weight) results in amelioration of muscle loss in tumour-bearing mice experimental cachexia. The effect of the agonist, which seems to be specific for white muscle extensor digitorum longus (EDL), is accompanied by an increase in the levels of the transcription factor MyoD and also the GLUT-4… (More)


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