Effects of the Nootropic Drug Nefiracetam on the GABAA Receptor-channel Complex in Dorsal Root Ganglion Neurons

@article{Huang1996EffectsOT,
  title={Effects of the Nootropic Drug Nefiracetam on the GABAA Receptor-channel Complex in Dorsal Root Ganglion Neurons},
  author={Chao-Sheng Huang and MA Jennyyan and W. Marszalec and T. Narahashi},
  journal={Neuropharmacology},
  year={1996},
  volume={35},
  pages={1251-1261}
}
The effects of nefiracetam on GABA-induced chloride currents were studied with rat dorsal root ganglion neurons in primary culture using the whole-cell patch-clamp technique. The dose-response curve for GABA-induced currents was shifted by 16 microM to lower concentrations by 10 microM nefiracetam while the maximal response was reduced by 22.84 +/- 0.68%. Thus at a low concentration (10 microM) of GABA, the chloride currents were potentiated by nefiracetam in a concentration-dependent manner… Expand
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