Effects of the NMDA-receptor antagonist ketamine on perceptual correlates of long-term potentiation within the nociceptive system.

@article{Klein2007EffectsOT,
  title={Effects of the NMDA-receptor antagonist ketamine on perceptual correlates of long-term potentiation within the nociceptive system.},
  author={Thomas Klein and Walter Magerl and Ursula Nickel and Hanns-Christian Hopf and J{\"u}rgen Sandk{\"u}hler and Rolf-Detlef Treede},
  journal={Neuropharmacology},
  year={2007},
  volume={52 2},
  pages={655-61}
}
We recently reported perceptual correlates of long-term potentiation (LTP) of synaptic strength within the nociceptive system demonstrating the functional relevance of LTP for human pain sensation. LTP is generally classified as NMDA-receptor dependent or independent. Here we show that low doses of the NMDA-receptor antagonist ketamine (0.25 mg/kg) prevented the long-term increase in perceived pain to electrical test stimuli, which was induced by high-frequency electrical stimulation (HFS) of… CONTINUE READING
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