Effects of the Mixed Mu/Kappa Opioid Nalbuphine on Cocaine-Induced Changes in Subjective and Cardiovascular Responses in Men

@article{Mello2005EffectsOT,
  title={Effects of the Mixed Mu/Kappa Opioid Nalbuphine on Cocaine-Induced Changes in Subjective and Cardiovascular Responses in Men},
  author={Nancy K. Mello and Jack H. Mendelson and Michelle B. Sholar and Maria Jaszyna-Gasior and Nathalie V. Goletiani and Arthur J. Siegel},
  journal={Neuropsychopharmacology},
  year={2005},
  volume={30},
  pages={618-632}
}
Kappa opioid agonists functionally antagonize some abuse-related and locomotor effects of cocaine, and reduce cocaine self-administration by rhesus monkeys. We compared the cardiovascular and subjective effects of acute doses of the mu/kappa opioid nalbuphine alone (5 mg/70 kg, intravenous (i.v.)), with cocaine alone (0.2 mg/kg, i.v.), and with nalbuphine+cocaine in combination, under placebo-controlled, double-blind conditions. Subjects met American Psychiatric Association Diagnostic and… 

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