Effects of the Medicinal Mushroom Agaricus blazei Murill on Immunity, Infection and Cancer

  title={Effects of the Medicinal Mushroom Agaricus blazei Murill on Immunity, Infection and Cancer},
  author={Geir Hetland and E. Johnson and Torstein Lyberg and Soosaipillai V Bernardshaw and Anne M A Tryggestad and Bj{\o}rn Grinde},
  journal={Scandinavian Journal of Immunology},
Agaricus blazei Murill (AbM) is an edible, medicinal mushroom of Brazilian origin. It is used traditionally against a range of diseases, including cancer and chronic hepatitis, and has been cultivated commercially for the health food market. AbM has recently been shown to have strong immunomodulating properties, which has led to increasing scientific interest. In this article, we review current knowledge as to the immunological properties of AbM, and its possible clinical use in connection with… 
Agaricus blazei Murill - immunomodulatory properties and health benefits
AbM-related benefits reviewed here include effects against cancer, infections, inflammation, allergy/ asthma and diabetes, and effects of AndoSanTM and other AbM-based extracts have been compared in a bacterial sepsis model.
Health Benefits of Medicinal Mushroom Agaricus subrufescens
This mushroom is rich in the immunomodulating polysaccharides, β-glucans, and has been shown to have antitumor, antiinfection, and antiallergic/-asthmatic properties in mouse models, in addition to antiinflammatory effects in inflammatory bowel disease patients.
An extract of the medicinal mushroom Agaricus blazei Murill can protect against allergy
This particular AbM extract may both prevent allergy development and be used as a therapeutical substance against established allergy.
Agaricus subrufescens: A review.
The Mushroom Agaricus blazei Murill Elicits Medicinal Effects on Tumor, Infection, Allergy, and Inflammation through Its Modulation of Innate Immunity and Amelioration of Th1/Th2 Imbalance and Inflammation
Agaricus blazei M is rich in the immunomodulating polysaccharides, β-glucans, and has been shown to have antitumor, anti-infection, and antiallergic/-asthmatic properties in mouse models, in addition to anti-inflammatory effects in inflammatory bowel disease patients.
Andosan™-An Anti-Allergic and Anti-Inflammatory Ingredient Prepared from Agaricus blazei Mushroom
An overview of the anti-allergic effects of Andosan™ in a mouse model for allergy and anti-inflammatory effects both in vitro, in healthy individuals and in patients with inflammatory bowel diseases is given.
eview ntimicrobial properties of the mushroom Agaricus blazei – ntegrative review ristiane
Infectious diseases associated with antimicrobial resistance are considered to represent an important public health problem. In this regard, the mushroom Agaricus blazei Murrill contains several
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Despite broad scientific evidence demonstrating relevant immunomodulatory properties of A. blazei Murrill, randomized clinical trials with human subjects are still needed in order for the mushroom to be put into clinical practice.


Therapeutic effects of substances occurring in higher Basidiomycetes mushrooms: a modern perspective.
This review highlights some of the recently isolated and identified substances of higher Basidiomycetes mushrooms origin that express promising antitumor, immune modulating, cardiovascular and
An Extract of the Mushroom Agaricus blazei Murill Administered Orally Protects Against Systemic Streptococcus pneumoniae Infection in Mice
The results suggest that AbM extract may be useful as additional prophylactic and possibly therapeutic treatment against bacterial and possibly other infections in humans.
Isolation of an antitumor compound from Agaricus blazei Murill and its mechanism of action.
It seems likely that the antitumor activity of ergosterol might be due to direct inhibition of angiogenesis induced by solid tumors, the first report of ergostol as an antiangiogenic substance.
Lack of carcinogenicity of lyophilized Agaricus blazei Murill in a F344 rat two year bioassay.
  • I. Lee, B. Kang, J. K. Roh, J. R. Kim
  • Biology
    Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association
  • 2008
Antitumor beta glucan from the cultured fruit body of Agaricus blazei.
Factors strongly suggest that a highly branched 1,3-beta-glucan segment forms the active center of the antitumor activity of A. blazei.
Anti-genotoxic effect of aqueous extracts of sun mushroom (Agaricus blazei Murill lineage 99/26) in mammalian cells in vitro.