Effects of the Japanese herbal medicine 'Inchinko-to' (TJ-135) on concanavalin A-induced hepatitis in mice.

@article{Yamashiki2000EffectsOT,
  title={Effects of the Japanese herbal medicine 'Inchinko-to' (TJ-135) on concanavalin A-induced hepatitis in mice.},
  author={Masayoshi Yamashiki and Akihito Mase and Iwao Arai and Xiao Xuan Huang and Tsutomu Nobori and Akira Nishimura and Satsuki Sakaguchi and Kyouichi Inoue},
  journal={Clinical science},
  year={2000},
  volume={99 5},
  pages={421-31}
}
Inchinko-to (TJ-135) is a herbal medicine consisting of three kinds of crude drugs, and in Japan it is administered mainly to patients with cholestasis. The present study evaluated the effects of TJ-135 on concanavalin A (con A)-induced hepatitis in mice in vivo and con A-induced cytokine production in vitro. When mice were pretreated with oral TJ-135 for 1 week before intravenous con A injection, the activities of serum aspartate aminotransferase (AST), alanine aminotransferase (ALT) and… CONTINUE READING

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When mice were pretreated with oral TJ-135 for 1 week before intravenous con A injection , the activities of serum aspartate aminotransferase ( AST ) , alanine aminotransferase ( ALT ) and lactate dehydrogenase ( LDH ) were significantly decreased 8 h after con A administration ( -82% , -96% and -66% respectively ) .
When mice were pretreated with oral TJ-135 for 1 week before intravenous con A injection , the activities of serum aspartate aminotransferase ( AST ) , alanine aminotransferase ( ALT ) and lactate dehydrogenase ( LDH ) were significantly decreased 8 h after con A administration ( -82% , -96% and -66% respectively ) .
When mice were pretreated with oral TJ-135 for 1 week before intravenous con A injection , the activities of serum aspartate aminotransferase ( AST ) , alanine aminotransferase ( ALT ) and lactate dehydrogenase ( LDH ) were significantly decreased 8 h after con A administration ( -82% , -96% and -66% respectively ) .
When mice were pretreated with oral TJ-135 for 1 week before intravenous con A injection , the activities of serum aspartate aminotransferase ( AST ) , alanine aminotransferase ( ALT ) and lactate dehydrogenase ( LDH ) were significantly decreased 8 h after con A administration ( -82% , -96% and -66% respectively ) .
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