Effects of the HIV-1 viral protein TAT on central neurotransmission: role of group I metabotropic glutamate receptors.

Abstract

Human immunodeficiency virus 1 (HIV-1)-associated dementia (HAD) represents a common complication of HIV-1 infection. Antiretroviral therapy has diminished its incidence, but it is insufficient to eradicate the problem. HAD depends on the presence of the virus in central nervous system (CNS), but the molecular mechanisms involved are not completely… (More)

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