Effects of the Ethyl Acetate Fraction of Alchornea triplinervia on Healing Gastric Ulcer in Rats

@article{Lima2011EffectsOT,
  title={Effects of the Ethyl Acetate Fraction of Alchornea triplinervia on Healing Gastric Ulcer in Rats},
  author={Zeila Pinheiro Lima and Fl{\'a}via Bonamin and Tamara Regina Calvo and Wagner Vilegas and Lourdes Campaner dos Santos and Ariane Leite Rozza and Cl{\'a}udia Helena Pellizzon and L{\'u}cia Regina Machado da Rocha and Cl{\'e}lia Akiko Hiruma-Lima},
  journal={Pharmaceuticals},
  year={2011},
  volume={4},
  pages={1423 - 1433}
}
Alchornea triplinervia (Spreng.) Muell. Arg (Euphorbiaceae) is a medicinal plant commonly used by people living in the Cerrado region of Brazil to treat gastrointestinal ulcers. We previously described the gastroprotective action of methanolic extract (ME) of Alchornea triplinervia and the ethyl acetate fraction (EAF) in increasing of prostaglandin E2 (PGE2) gastric levels in the mucosa. In this work we evaluated the effect of EAF in promoting the healing process in rats with acetic acid… Expand
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References

SHOWING 1-10 OF 33 REFERENCES
Brazilian medicinal plant acts on prostaglandin level and Helicobacter pylori.
TLDR
Results suggest that methanolic extract of A. triplinervia did not show acute toxicity, but exhibited an antisecretory property, anti-H. Expand
A new method for the production of chronic gastric ulcer in rats and the effect of several drugs on its healing.
TLDR
The studies of the healing process of the produced ulcer and the usefulness for the assay method of the curative drugs of gastric ulcer are dealt with. Expand
Influence of aging on gastric ulcer healing activities of cimetidine and omeprazole.
TLDR
It is indicated that cimetidine and omeprazole have potent gastric ulcer healing actions in 8- and 48- week-old rats, as well as potent serum gastrin-elevating actions, but both drugs are ineffective in 96-week-old Rats, which have lost their gastin-e Elevating actions. Expand
Antiangiogenic effect of a highly selective cyclooxygenase-2 inhibitor on gastric ulcer healing in rats.
TLDR
The findings that highly selective COx-2 inhibitor delayed ulcer healing in rats and impaired angiogenesis in the ulcer base raise cautions regarding the use of COX-2 inhibitors in patients with gastric ulcers. Expand
Effects of antisecretory agents on angiogenesis during healing of gastric ulcers
TLDR
It is suggested that PPIs increase the expression of CXCR4 mRNA and thus promote vessel regeneration and maturation, facilitating ulcer healing. Expand
An overview of acetic acid ulcer models--the history and state of the art of peptic ulcer research.
TLDR
It is concluded that acetic acid ulcer models are quite useful for various studies related to peptic ulcers. Expand
Cell proliferation in the gastric epithelium of the ulcer rat
TLDR
The unexpected finding in the ulcer rats of decreased LI in undamaged oxyntic and antral epithelium may be caused by a block of the G1 restriction point in the cell cycle. Expand
Plants of the American continent with antiulcer activity.
TLDR
The present work is a literature survey of plant extracts from the American continent that have been reported to show antiulcer activity and intends to aid the researchers in the study of natural products appropriate to the treatment of stomach and intestinal diseases, in general, and peptic ulcer in particular. Expand
Antioxidant properties of natural compounds used in popular medicine for gastric ulcers.
  • M. Repetto, S. Llesuy
  • Medicine
  • Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas
  • 2002
TLDR
The role of natural antioxidants derived from popular plants to reduce or prevent the oxidative stress in gastric ulcer induced by ethanol is considered. Expand
Adaptation of gastric mucosa to chronic alcohol administration is associated with increased mucosal expression of growth factors and their receptor.
TLDR
Adaptation of gastric mucosa to chronic alcohol administration is associated with increased cell proliferation and increased expression of mucosal EGF, TGF alpha and EGFR. Expand
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