Effects of the Direct Lipoprotein-Associated Phospholipase A2 Inhibitor Darapladib on Human Coronary Atherosclerotic Plaque

@article{Serruys2008EffectsOT,
  title={Effects of the Direct Lipoprotein-Associated Phospholipase A2 Inhibitor Darapladib on Human Coronary Atherosclerotic Plaque},
  author={P. Serruys and H. Garcia-Garcia and P. Buszman and P. Erne and S. Verheye and M. Aschermann and Henrikus Duckers and Oyvind Bleie and D. Dudek and H. B{\o}tker and C. von Birgelen and Don D'Amico and Tammy Hutchinson and A. Zambanini and F. Mastik and G. van Es and A. V. D. van der Steen and D. Vince and P. Ganz and C. Hamm and W. Wijns and A. Zalewski},
  journal={Circulation},
  year={2008},
  volume={118},
  pages={1172-1182}
}
Background— Lipoprotein-associated phospholipase A2 (Lp-PLA2) is expressed abundantly in the necrotic core of coronary lesions, and products of its enzymatic activity may contribute to inflammation and cell death, rendering plaque vulnerable to rupture. Methods and Results— This study compared the effects of 12 months of treatment with darapladib (an oral Lp-PLA2 inhibitor, 160 mg daily) or placebo on coronary atheroma deformability (intravascular ultrasound palpography) and plasma high… Expand
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