Effects of the CYP2D6*10 alleles and co-medication with CYP2D6-dependent drugs on risperidone metabolism in patients with schizophrenia.

@article{Yagihashi2009EffectsOT,
  title={Effects of the CYP2D6*10 alleles and co-medication with CYP2D6-dependent drugs on risperidone metabolism in patients with schizophrenia.},
  author={Tatsuhiko Yagihashi and Masafumi Mizuno and Bun Chino and Yuji Sato and Kei Sakuma and Toru Takebayashi and Takahashi Takao and Kenjiro Kosaki},
  journal={Human psychopharmacology},
  year={2009},
  volume={24 4},
  pages={301-8}
}
OBJECTIVE Risperidone is converted to 9-hydroxyrisperidone by CYP2D6. Two parameters were used to examine the influences of CYP2D6 polymorphism and of co-medication on risperidone metabolism: the risperidone:9-hydroxyrisperidone concentration ratio (R:9-OHR ratio) and the sum of the risperidone and 9-hydroxyrisperidone concentrations divided by the dose (C:D ratio). We evaluated the effect of the CYP2D6*10 allele, which is a prevalent mutant allele among East Asians. METHODS Genotyping using… CONTINUE READING