Effects of the Antioxidative Vitamins A, C and E on Liver Metastasis and Intrametastatic Lipid Peroxidation in BOP-Induced Pancreatic Cancer in Syrian Hamsters

@article{Heukamp2005EffectsOT,
  title={Effects of the Antioxidative Vitamins A, C and E on Liver Metastasis and Intrametastatic Lipid Peroxidation in BOP-Induced Pancreatic Cancer in Syrian Hamsters},
  author={I. Heukamp and M. Kilian and J. I. Gregor and A. Neumann and C. Jacobi and H. Guski and I. Schimke and M. Walz and F. Wenger},
  journal={Pancreatology},
  year={2005},
  volume={5},
  pages={403 - 409}
}
Background/Aims: Antioxidative vitamins are known to inhibit metastasis. Therefore we evaluated the impact of vitamins A (retinol), C (ascorbic acid) and E (α-tocopherol) on liver metastasis in a model of ductal pancreatic adenocarcinoma in hamster. Methods: One hundred and twenty male Syrian hamsters were randomized into 8 groups (Gr.) (n = 15). Gr. 1–4 were given 0.5 ml normal saline subcutaneously (s.c.) weekly, whereas Gr. 5–8 received 10 mg N-nitrosobis(2-oxopropyl)amine (BOP)/kg body… Expand
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