Effects of the Antiarrhythmic Drug Dofetilide on Myocardial Electrical Activity: A Computer Modelling Study


Dofetilide selectively inhibits the rapid component of the delayed potassium current (IKr). In this work, a mathematical model of dofetilide effects on IKr has been developed. This model has been incorporated to the Luo and Rudy (II) model of guinea pig ventricular action potential and the effect of different dofetilide concentrations on the action… (More)


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