Effects of the 5-HT6 receptor agonist ST 1936 on depression- and anhedonia-like experimental models

@article{Scheggi2011EffectsOT,
  title={Effects of the 5-HT6 receptor agonist ST 1936 on depression- and anhedonia-like experimental models},
  author={Simona Scheggi and Giovanna Marchese and Franco Borsini and Fabio Bordi and Maria Graziella de Montis},
  journal={Behavioural Brain Research},
  year={2011},
  volume={224},
  pages={35-43}
}
View on Elsevier
doi.org
6 Citations
Highly Influential Citations
1
Background Citations
5
Methods Citations
1

6 Citations

Citation Type

Citation Type

Antidepressant-like activity of EMD 386088, a 5-HT6 receptor partial agonist, following systemic acute and chronic administration to rats
TLDR
The obtained findings suggest that EMD 386088 produces antidepressant-like activity after systemic acute and chronic administration which may result from direct stimulation of 5-HT6 receptors.
Development of novel serotonin 5-HT6 and dopamine D2 receptor ligands and MAO A inhibitors - Synthesis, structure-activity relationships and pharmacological characterization
TLDR
This thesis is focused on further exploring the SAR around tetrahydropyridine/piperidine indoles by introduction of substituents and/or bioisosteric replacements of the indole core with the aim of developing novel compounds acting at the dopaminergic and serotonergic systems in the brain.
Withdrawal from repeated treatment with ethanol induces a protracted decrease in novelty-seeking behavior and enhancement of environmental habituation in mice
Serotonin receptor of type 6 (5-HT6) in human prefrontal cortex and hippocampus post-mortem: An immunohistochemical and immunofluorescence study
Exposure to Hypobaric Hypoxia and Reoxygenation Induces Transient Anxiety-Like Behavior in Rat
TLDR
It is suggested that initial exposure to HH increases transient anxiety-like behavior in rats followed by gradual improvement in mood state on prolonged exposure, and the involvement of serotonergic system in Mood state alteration at high altitude following chronic exposure and reoxygenation is indicated.
GPCR and RTK Regulation in Neurons: The Impact of Stress on GPCR and RTK signalling and Crosstalk

References

SHOWING 1-10 OF 70 REFERENCES
Biochemical and Behavioral Evidence for Antidepressant-Like Effects of 5-HT6 Receptor Stimulation
TLDR
5-HT6 receptor stimulation may be a mechanism initiating some of the biochemical and behavioral outcomes of 5-HT reuptake inhibitors, such as fluoxetine, which indicates that selective 5- HT6 receptor agonists may represent a novel antidepressant drug class.
Antidepressant and anxiolytic effects of selective 5-HT6 receptor agonists in rats
TLDR
Findings suggest that 5-HT6 receptor agonists may represent a new class of potential antidepressant and anxiolytic compounds and could possess a number of advantages over currently available treatments, including rapid onset of anxIOlytic efficacy.
Imipramine and fluoxetine prevent the stress‐induced escape deficits in rats through a distinct mechanism of action
TLDR
It was concluded that in rats, the efficacy of IMI in counteracting the stress-induced behavioral sequelae is mainly mediated by the activation of D1 dopamine receptors, whereas that of FLX is largely dependent upon the stimulation of post-synaptic 5-HT1A receptors.
Potential role of the 5-HT6 receptor in depression and anxiety: an overview of preclinical data.
Procognitive 5-HT6 antagonists in the rat forced swimming test: potential therapeutic utility in mood disorders associated with Alzheimer's disease.
Behavioral pharmacology: potential antidepressant and anxiolytic properties.
Crucial role of D1 dopamine receptors in mediating the antidepressant effect of imipramine
Study into a possible mechanism responsible for the antidepressant-like activity of the selective 5-HT6 receptor antagonist SB-399885 in rats.
TLDR
The results described in the present paper indicate that the anti-immobility activity of SB-399885 is not connected with 5-HT innervation, and that D(1)- and D(2-like receptors and alpha(2)-adrenoceptors are involved in this action.
Effects of the brain-penetrant and selective 5-HT6 receptor antagonist SB-399885 in animal models of anxiety and depression
E-6801, a 5-HT6 receptor agonist, improves recognition memory by combined modulation of cholinergic and glutamatergic neurotransmission in the rat
TLDR
This is the first study to demonstrate that E-6801, a potent 5-HT6 receptor agonist, improves recognition memory by combined modulation of cholinergic and glutamatergic neurotransmission.
...
1
2
3
4
5
...