Effects of the 5-HT6 receptor agonist ST 1936 on depression- and anhedonia-like experimental models

@article{Scheggi2011EffectsOT,
  title={Effects of the 5-HT6 receptor agonist ST 1936 on depression- and anhedonia-like experimental models},
  author={Simona Scheggi and Giovanna Marchese and Franco Borsini and Fabio Bordi and Maria Graziella de Montis},
  journal={Behavioural Brain Research},
  year={2011},
  volume={224},
  pages={35-43}
}
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References

SHOWING 1-10 OF 70 REFERENCES
Biochemical and Behavioral Evidence for Antidepressant-Like Effects of 5-HT6 Receptor Stimulation
TLDR
5-HT6 receptor stimulation may be a mechanism initiating some of the biochemical and behavioral outcomes of 5-HT reuptake inhibitors, such as fluoxetine, which indicates that selective 5- HT6 receptor agonists may represent a novel antidepressant drug class.
Antidepressant and anxiolytic effects of selective 5-HT6 receptor agonists in rats
TLDR
Findings suggest that 5-HT6 receptor agonists may represent a new class of potential antidepressant and anxiolytic compounds and could possess a number of advantages over currently available treatments, including rapid onset of anxIOlytic efficacy.
Imipramine and fluoxetine prevent the stress‐induced escape deficits in rats through a distinct mechanism of action
TLDR
It was concluded that in rats, the efficacy of IMI in counteracting the stress-induced behavioral sequelae is mainly mediated by the activation of D1 dopamine receptors, whereas that of FLX is largely dependent upon the stimulation of post-synaptic 5-HT1A receptors.
Study into a possible mechanism responsible for the antidepressant-like activity of the selective 5-HT6 receptor antagonist SB-399885 in rats.
TLDR
The results described in the present paper indicate that the anti-immobility activity of SB-399885 is not connected with 5-HT innervation, and that D(1)- and D(2-like receptors and alpha(2)-adrenoceptors are involved in this action.
E-6801, a 5-HT6 receptor agonist, improves recognition memory by combined modulation of cholinergic and glutamatergic neurotransmission in the rat
TLDR
This is the first study to demonstrate that E-6801, a potent 5-HT6 receptor agonist, improves recognition memory by combined modulation of cholinergic and glutamatergic neurotransmission.
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