Effects of the 5-HT(3) receptor antagonist ondansetron on the ketamine- and dizocilpine-induced place preferences in mice.

@article{Suzuki1999EffectsOT,
  title={Effects of the 5-HT(3) receptor antagonist ondansetron on the ketamine- and dizocilpine-induced place preferences in mice.},
  author={Tsutomu Suzuki and Toshiaki Aoki and Hideaki Kato and Mitsuaki Yamazaki and Miwa Misawa},
  journal={European journal of pharmacology},
  year={1999},
  volume={385 2-3},
  pages={99-102}
}
The effects of the 5-HT(3) receptor antagonist ondansetron on the ketamine- and dizocilpine-induced place preferences in mice were examined. The non-competitive NMDA receptor antagonists ketamine (1. 0-10 mg/kg, i.p.) and dizocilpine (0.1 and 0.2 mg/kg, i.p.) each produced a place preference in a dose-dependent manner. The ketamine (10 mg/kg)- and dizocilpine (0.2 mg/kg)-induced place preferences were dose-dependently blocked by pretreatment with ondansetron (0. 03-0.1 mg/kg, s.c.). These… CONTINUE READING

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