Effects of the 5‐HT3 receptor antagonist, GR38032F, on raised dopaminergic activity in the mesolimbic system of the rat and marmoset brain

@article{Costall1987EffectsOT,
  title={Effects of the 5‐HT3 receptor antagonist, GR38032F, on raised dopaminergic activity in the mesolimbic system of the rat and marmoset brain},
  author={Brenda Costall and Annette M. Domeney and Robert J. Naylor and Michael Brian Tyers},
  journal={British Journal of Pharmacology},
  year={1987},
  volume={92}
}
1 The ability of the selective 5‐HT3 receptor antagonist GR38032F to reduce raised mesolimbic dopaminergic activity was studied in behavioural experiments in the rat and marmoset. 2 GR38032F injected into the nucleus accumbens (0.01–1 ng) or peripherally (0.01–1 mg kg−1 i.p.) inhibited the locomotor hyperactivity caused by the acute intra‐accumbens injection of amphetamine (10 μg) in the rat. Similar treatments with sulpiride and fluphenazine also inhibited the amphetamine‐induced hyperactivity… Expand
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