Effects of the 3β-hydroxysteroid dehydrogenase inhibitor trilostane on luteal progesterone production in the dog.

@article{Gier2011EffectsOT,
  title={Effects of the 3β-hydroxysteroid dehydrogenase inhibitor trilostane on luteal progesterone production in the dog.},
  author={J. de Gier and C.H.J. Wolthers and S. Galac and A. C. Okkens and H. Kooistra},
  journal={Theriogenology},
  year={2011},
  volume={75 7},
  pages={
          1271-9
        }
}
  • J. de Gier, C.H.J. Wolthers, +2 authors H. Kooistra
  • Published 2011
  • Chemistry, Medicine
  • Theriogenology
  • Interference with the pregnancy-maintaining influence of progesterone is the basis of most methods for termination of unwanted pregnancy in dogs. The currently available methods are based on induction of luteolysis or blocking of the progesterone receptor. Inhibition of progesterone synthesis using a competitive inhibitor of 3β-hydroxysteroid dehydrogenase (3β-HSD) could be another strategy to terminate unwanted pregnancies. In this study we investigated the effects of the 3β-HSD inhibitor… CONTINUE READING
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