• Corpus ID: 21400385

Effects of the (+/-)-, (+)- and (-)-forms of propranolol, timolol and metoprolol on noradrenergic transmission in the rat isolated right ventricle.

@article{Bradley1984EffectsOT,
  title={Effects of the (+/-)-, (+)- and (-)-forms of propranolol, timolol and metoprolol on noradrenergic transmission in the rat isolated right ventricle.},
  author={L Bradley and Sheila Anne Doggrell},
  journal={Archives internationales de pharmacodynamie et de therapie},
  year={1984},
  volume={270 1},
  pages={
          61-78
        }
}
  • L. BradleyS. Doggrell
  • Published 1 July 1984
  • Biology, Chemistry, Medicine
  • Archives internationales de pharmacodynamie et de therapie
The effects of the (+/-)-, (+)- and (-)-forms of propranolol, timolol and metoprolol on noradrenergic transmission have been studied in the rat isolated right ventricle. (+)- And (-)-propranolol (10(-5) M) inhibited the accumulation of radioactivity from [3H]-noradrenaline. The decline in the spontaneous outflow of radioactivity, following loading of the tissue with [3H]-noradrenaline, was reduced by (+)- and (-)-propranolol (10(-5) M), (+)-timolol (10(-5) M), (-)-timolol (10(-6) - 10(-5) M… 
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