Effects of the α2/α3-subtype-selective GABAA receptor positive allosteric modulator KRM-II-81 on pain-depressed behavior in rats: comparison with ketorolac and diazepam

@article{Moerke2019EffectsOT,
  title={Effects of the $\alpha$2/$\alpha$3-subtype-selective GABAA receptor positive allosteric modulator KRM-II-81 on pain-depressed behavior in rats: comparison with ketorolac and diazepam},
  author={Megan J Moerke and Guanguan Li and Lalit K Golani and James M Cook and Sidney Stevens Negus},
  journal={Behavioural Pharmacology},
  year={2019},
  volume={30},
  pages={452 - 461}
}
This study examined effects of the α2/α3-subtype-selective GABAA receptor positive allosteric modulator KRM-II-81 in an assay of pain-related behavioral depression. Adult, male Sprague-Dawley rats responded for electrical brain stimulation in a frequency-rate intracranial self-stimulation (ICSS) procedure. Intraperitoneal injection of 1.8% lactic acid served as an acute noxious stimulus to depress ICSS. Effects of KRM-II-81 were evaluated in the absence and presence of the acid noxious stimulus… Expand
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