Effects of the α1-adrenoceptor agonist phenylephrine on SART stress-induced orthostatic hypotension in rats

@inproceedings{Funakami2010EffectsOT,
  title={Effects of the α1-adrenoceptor agonist phenylephrine on SART stress-induced orthostatic hypotension in rats},
  author={Yoshinori Funakami and Eiji Itoh and Taeko Hata and Tetsuyuki Wada and Seiji Ichida},
  booktitle={BioPsychoSocial medicine},
  year={2010}
}
BACKGROUND Specific alternation of rhythm in temperature (SART)-stressed rats, an animal model of autonomic imbalance, exhibit low blood pressure and tachycardia during consciousness and under anesthesia. In addition, these rats easily develop orthostatic hypotension (OH) as a response to postural manipulation. Hence, we studied the influence of the adrenalin α1-receptor agonist phenylephrine on stress-induced OH in SART-stressed rats and unstressed rats. METHODS Male Wistar rats weighing 250… CONTINUE READING
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