Effects of thalidomide on long-term bone marrow cultures from patients with myelodysplastic syndromes: induction of IL-10 expression in the stromal layers.

Abstract

The purpose of this study was to investigate the in vitro effects of thalidomide on long-term bone marrow cultures from patients with myelodysplastic syndrome. We demonstrated that thalidomide induced an increase in granulocyte-macrophage colony forming unit numbers and in IL-10 expression. Thalidomide also promoted a slight increase in IL-6, IL-1β and TNF-α expression in the stromal layers. The numbers of erythroid burst forming units, the apoptosis rate of hematopoietic cells, and VEGF and TNF-α expression levels in culture supernatants were not modulated. Our results indicate a participation of thalidomide upon the hematopoietic microenvironment of patients with myelodysplastic syndromes, especially in the up regulation of IL-10.

DOI: 10.1016/j.leukres.2011.03.027

Statistics

0501001502011201220132014201520162017
Citations per Year

96 Citations

Semantic Scholar estimates that this publication has 96 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Lazarini2011EffectsOT, title={Effects of thalidomide on long-term bone marrow cultures from patients with myelodysplastic syndromes: induction of IL-10 expression in the stromal layers.}, author={Mariana Lazarini and Fabiola Traina and Sheila Maria Brochado Winnischofer and Fernando F. Costa and Mary Luci de Souza Queiroz and Sara Teresinha Olalla Saad}, journal={Leukemia research}, year={2011}, volume={35 8}, pages={1102-7} }