Effects of tetrodotoxin on excitability of squid giant axons in sodium-free media.

@article{Watanabe1967EffectsOT,
  title={Effects of tetrodotoxin on excitability of squid giant axons in sodium-free media.},
  author={Akira Watanabe and Ichiji Tasaki and Igor Singer and L M Lerman},
  journal={Science},
  year={1967},
  volume={155 3758},
  pages={95-7}
}
The effect of tetrodotoxin on excitability of internally perfused squid giant axons immersed in various sodium-free media was examined. Action potentials were found to be suppressed by this substance, with or without sodium ion in the external medium. Tetrodotoxin showed a strong suppressive effect upon action potentials produced in media containing salts of only divalent cations (CaCl(2), CaBr(2), SrCl(2), or BaCl(2)). Our findings concerning the action of tetrodotoxin do not support the… CONTINUE READING

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